however, overexpression of wnk1 in hek293 cells exerts no detectable effect on the activity of known substrates which indicates that wnk kinases belong to a novel signal pathway 高表达wnk激酶家族的一个成员??wnk1在hek293细胞中,没有检测到已知的作用底物生物活性的变化,说明wnk激酶属于一个新的信号传导通路。